Review the Sepsis in Obstetrics guideline available on the intranet.

Send blood cultures (10mls blood in each bottle)

Antimicrobial recommendations

Treatment duration = IV + oral = 7 days

Recommended Antibiotic

Cefotaxime 2g every 8 hours IV

AND

Metronidazole 400mg every 8 hours orally (500mg every 8 hours IV if oral route not available)

Severe sepsis with hypotension

ADD

Gentamicin as per NHS Lothian intranet calculator if on or after day 3 post partum otherwise follow guidance on Sepsis in Obstetrics guideline.

AND

Clindamycin 600mg every 6 hours IV

Penicillin allergy

Clindamycin 600mg every 6 hours IV

AND

Gentamicin as per NHS Lothian intranet calculator if on or after day 3 post partum otherwise follow guidance on Sepsis in Obstetrics guideline.

 

MRSA positive

  • Add vancomycin using NHS Lothian AMT intranet calculator choose trough level of 15-20mg/ml.

Cefotaxime and clindamycin are associated with C.diff infection.