An unstable patient should be managed in accordance with emergency protocols.
A stable patient should have a group and save, FBC and if appropriate a βhCG taken.
Initial diagnosis, management and scans or biochemical results of non tubal pregnancies must be discussed with a consultant gynaecologist. A gynaecologist with early pregnancy expertise should be involved in planning ongoing care and management.
Site of ectopic |
Ultrasound features |
Biochemical investigations |
Management options |
Cervical pregnancy |
Empty uterine cavity Barrel shaped cervix Gestational sac (GS) below the level of the internal cervical os Blood flow around the GS Absence of sliding signi |
Serum βhCG |
Consider systemic methotrexate if:
Consider systemic methotrexate +/- surgical debulking +/- intracervical methotrexate if:
|
Caesarean ectopic |
Empty uterine cavity GS or trophoblast located anteriorly at the level of the internal cervical os Embedded at site of previous caesarean section Thin or absent myometrium between GS and bladder Evidence of prominent trophoblastic circulation on doppler examination Empty endocervical canal |
Not routinely required |
Consider MRI if diagnosis is in doubt Treatment requires individualised care 1st trimester options:
If the pregnancy continues after the first trimester then the patient must be highlighted to the Obstetric Consultant leading the patient’s care as there is a risk of invasive placentation. |
Interstitial pregnancy |
Empty uterine cavity GS located in the intramural part of the fallopian tube <5mm of myometrium in all planes Presence of interstitial lineii |
Consider sequential βhCG |
Consider MRI to aid diagnosis following discussion with gynaecology consultant Medical management with systemic methotrexate should be considered 1st line Consider expectant management in those with low initial βhCG levels |
Cornual pregnancy |
GS mobile and separate from the uterus and surrounded by myometrium Vascular pedicle adjoining the unicornuate uterus |
Consider sequential βhCG 48 hours apart |
Surgical management should be 1st line Removal of the rudimentary horn should be undertaken |
Ovarian pregnancy |
Empty uterus Internal anechoic area on the ovary |
Consider sequential βhCG 48 hours apart |
Laparoscopic management should be 1st line |
Abdominal pregnancy |
Empty uterus GS surrounded by loops of bowel and separated from them by peritoneum Mobile mass when pressing with the transvaginal probe |
βhCG |
Laparoscopic management should be 1st line. |
Heterotopic pregnancy |
Intrauterine pregnancy and co-existing ectopic pregnancy |
Not required |
Management needs to be individualised based on the intrauterine pregnancy and wishes of the patient Surgical management is 1st line with salpingectomy of the ectopic Systemic methotrexate should only be used if the intrauterine pregnancy Is non-viable or patient wishes termination Scan following surgery to assess viability of intrauterine pregnancy |
i Sliding sign: the vaginal probe is used to apply pressure onto the cervix. In a miscarriage, the gestational sac slides against the cervical canal, but does not do so in a pregnancy implanted in the endocervix or caesarean section scar.
ii Interstitial line sign: an echogenic line from the mass to the endometrial echo.