RIE target INR for mechanical prostheses 

Prosthesis thrombogenicity

Patient related risk factors:

·        Mitral or tricuspid valve replacement

·        Previous thromboembolism

·        Atrial fibrillation

·        Mitral stenosis of any degree

·        LVEF less than 35%

 

No risk factors

1 risk factor or more

Low

(Carbomedics, Medtronic Hall, ATS, Medtronic Open-Pivot, St Jude Medical, On-X, Sorin Bicarbon)

Target INR 2.5 (2.0-3.0)

Target INR 3.0 (2.5-3.5)

Medium

(Other bileaflet valves with insufficient data)

Target INR 3.0 (2.5-3.5)

Target INR 3.5 (3.0-4.0)

High

(Lillehei-Kaster, Omniscience, Starr[1]Edwards (ball-cage), Bjork-Shiley and other tilting-disc valves)

Target INR 3.5 (3.0-4.0)

Target INR 4.0 (3.5-4.5)