Warning

Stop unnecessary antibiotics and/or PPIs.

70% respond to metronidazole (MTZ) in 5 days; 92% in 14 days. 

If severe symptoms or signs (below) should treat with oral vancomycin, review progress closely and/or consider hospital referral.

Definition of severe: T >38.5oC, or WCC >15, or rising creatinine or signs/symptoms of severe colitis.

Drug details

Drug

1st episode:
Metronidazole (MTZ)

Dosage

400mg TDS

Duration

10 days

Drug

2nd episode/severe/type 027:
Oral Vancomycin

Dosage

125mg QDS

Duration

10 days

Recurrent disease:
Discuss with infection specialist.

Editorial Information

Last reviewed: 22/03/2021

Next review date: 22/03/2024

Author(s): NHS Lanarkshire Antimicrobial Management Committee, Dr Dundas, Dr Hylands, S McCormick.

Approved By: AMC; ADTC

Reviewer name(s): NHS Lanarkshire Antimicrobial Management Committee.