ACE inhibitor (Enalapril 2.5 - 40mg/day (uptitrated as tolerated) vs placebo, asymptomatic heart failure

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Study population:

Patients with asymptomatic heart failure (NYHA class I) due to left ventricular systolic dysfunction (ejection fraction ≤0.35)

Comments:

Mean age of enrolled patients was 60 years.

Treatment reduced the incidence of congestive heart failure and related hospital admissions

 

Outcome Duration NNT Annualised NNT
Prevent one death (any cause) 34 months(mean followup)

88

251

References

The Consensus Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure. The New England Journal of Medicine. 1987; 316(23): 1429-1435