Intrahepatic Cholestasis of Pregnancy (ICP) or Obstetric Cholestasis (OC) (1137)

Warning

Please report any inaccuracies or issues with this guideline using our online form

Prevalence is influenced by genetic and environmental aspects.

In the UK ICP affects 7:1000 pregnancies – it is more common in Indian – Asian or Pakistani – Asian women where it affects 12-15:1000.

It is characterised by the presence of an itch with no visible rash and raised bile acid concentration of 19 micro mol/L or more.

The onset of symptoms is most common in the 3rd trimester but can be earlier in pregnancy.

Important points to remember:

  • Alternative diagnosis (such as pre eclampsia) should always be considered before a diagnosis of ICP is made
  • It is possible for other conditions to co-exist
  • Pruritis and raised bile acid concentrations should return to normal after birth (persistently elevated levels may point to other diagnosis such as non alcoholic fatty liver)
  • Around 25% of pregnant women develop itching – the majority of these do not have and do not develop ICP

Resources

Use the button below to access this item.

Access this resource

Editorial Information

Last reviewed: 26/03/2024

Next review date: 27/02/2029

Author(s): Mandy Reid; Laura Hopper.

Version: 2

Approved By: Maternity Clinical Governance Group

Document Id: 1137