Centrally acting antihypertensive drugs (Formulary)

Caution in the elderly: For centrally-acting antihypertensives, prescription potentially inappropriate, unless clear intolerance of, or lack of efficacy with, other classes of antihypertensives (generally less well tolerated by older people). 

See BNF: Prescribing in the elderly. 

CLONIDINE

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Injection 150 micrograms/1mL (specialist use in High Dependency Units only). 

METHYLDOPA

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Tablets 250mg (specialist recommendation only)

Dosage:

Initially 250mg 2 to 3 times daily, increased gradually at intervals of 2 or more days, maximum 3 grams daily.

MOXONIDINE

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Tablets 200 micrograms, 300 micrograms, 400 micrograms (specialist recommendation only)

Dosage:

200 micrograms once daily in the morning, increased if necessary after 3 weeks to 400 micrograms daily in 1 to 2 divided doses; maximum 600 micrograms daily in 2 divided doses (maximum single dose 400 micrograms).

Editorial Information

Document Id: F041