Important: Therapy notes
MHRA advice: Intravenous paracetamol (Perfalgan▼): risk of accidental overdose (December 2014) (www.gov.uk)
Risk Minimisation Materials: paracetamol 10mg/mL solution for infusion training poster
- Paracetamol caplets may be easier to swallow than standard tablets and are preferred by many patients. Caplets may be supplied on a prescription for paracetamol tablets.
- The salt content of dispersible formulations of paracetamol and co-codamol may be unsuitable for some patients.
Important: Formulation and dosage details
Formulation:
TabletsOTC 500mg
Dosage:
Adults 50kg and over: 1 gram up to 4 times daily.
Consider dose reduction in patients with low body weight (less than 50kg), renal/hepatic impairment, chronic malnutrition, or chronic alcoholism to 15mg/kg/dose up to 4 times daily (to a maximum of 3 grams/day)
Important: Formulation and dosage details
Formulation:
Soluble tabletsOTC 500mg
Dosage:
Adults 50kg and over: 1 gram up to 4 times daily.
Consider dose reduction in patients with low body weight (less than 50kg), renal/hepatic impairment, chronic malnutrition, or chronic alcoholism to 15mg/kg/dose up to 4 times daily (to a maximum of 3 grams/day)
Important: Formulation and dosage details
Formulation:
Oral suspensionOTC 120mg/5mL, 250mg/5mL
Dosage:
Adults 50kg and over: 1 gram up to 4 times daily.
Consider dose reduction in patients with low body weight (less than 50kg), renal/hepatic impairment, chronic malnutrition, or chronic alcoholism to 15mg/kg/dose up to 4 times daily (to a maximum of 3 grams/day)
Important: Formulation and dosage details
Formulation:
SuppositoriesOTC 60mg, 120mg, 240mg, 500mg
Dosage:
Adults 50kg and over: 1 gram up to 4 times daily.
Consider dose reduction in patients with low body weight (less than 50kg), renal/hepatic impairment, chronic malnutrition, or chronic alcoholism to 15mg/kg/dose up to 4 times daily (to a maximum of 3 grams/day)
Important: Formulation and dosage details
Formulation:
Intravenous infusion 500mg/50mL, 1 gram/100mL
Dosage:
Adults 50kg and over: 1 gram up to 4 times daily.
Consider dose reduction in patients with low body weight (less than 50kg), renal/hepatic impairment, chronic malnutrition, or chronic alcoholism to 15mg/kg/dose up to 4 times daily (to a maximum of 3 grams/day)
Notes:
Note: Paracetamol infusion:
- Is 100% bioavailable and there is a greater risk of toxicity so should only be prescribed where clinically indicated. Review the prescription regularly.
- Should only be used when the patient is ‘nil by mouth’, or has swallowing difficulty which is not overcome by the use of suspension.
- Must be given in lower doses to patients under 50kg.
- Maximum daily dose must not exceed 3 grams in patient with renal/hepatic impairment, chronic malnutrition, chronic alcoholism.
- Increase the minimum interval between each dose to 6 hours if creatinine clearance is less than 30mL/min.
- Is more effective than paracetamol suppositories.