Drugs that enhance neuromuscular transmission (Formulary)

Neostigmine, pyridostigmine and immunosuppressants, eg prednisolone (Corticosteroids), azathioprine (Drugs affecting the immune response), are used to treat myasthenia gravis, whereas edrophonium is used in the diagnosis.

PYRIDOSTIGMINE

Important: Therapy notes

  • Gastro-intestinal side-effects are common and can be treated with the antimuscarinic propantheline bromide (non-Formulary).

Important: Formulation and dosage details

Formulation:

Tablets 60mg

Dosage:

By mouth, 30 to 120mg at suitable intervals throughout day. Doses exceeding 360mg daily should only be prescribed in consultation with a specialist.  

EDROPHONIUM

Important: Therapy notes

  • Stock is held in Raigmore Hospital emergency drug cupboard.

Important: Formulation and dosage details

Formulation:

Injection 10mg/mL unlicensed (s)

NEOSTIGMINE

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Injection 2·5mg/mL (s)

Editorial Information

Document Id: F281